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C-5a-substituted validamine type glycosidase inhibitors.
- Source :
-
Carbohydrate research [Carbohydr Res] 2017 Feb 22; Vol. 440-441, pp. 1-9. Date of Electronic Publication: 2017 Jan 13. - Publication Year :
- 2017
-
Abstract
- A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Agrobacterium chemistry
Agrobacterium enzymology
Animals
Bacterial Proteins chemistry
Carbohydrate Conformation
Cattle
Enzyme Inhibitors chemical synthesis
Escherichia coli chemistry
Escherichia coli enzymology
Fungal Proteins chemistry
Hydrophobic and Hydrophilic Interactions
Inositol chemical synthesis
Inositol chemistry
Kinetics
Saccharomyces cerevisiae chemistry
Saccharomyces cerevisiae enzymology
beta-Galactosidase chemistry
beta-Glucosidase chemistry
Bacterial Proteins antagonists & inhibitors
Enzyme Inhibitors chemistry
Fungal Proteins antagonists & inhibitors
Inositol analogs & derivatives
beta-Galactosidase antagonists & inhibitors
beta-Glucosidase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1873-426X
- Volume :
- 440-441
- Database :
- MEDLINE
- Journal :
- Carbohydrate research
- Publication Type :
- Academic Journal
- Accession number :
- 28135569
- Full Text :
- https://doi.org/10.1016/j.carres.2017.01.006