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TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Mar 04; Vol. 484 (2), pp. 311-317. Date of Electronic Publication: 2017 Jan 24. - Publication Year :
- 2017
-
Abstract
- Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric cancer. In this study, we showed that Tipα significantly down-regulated the expression of EMT-related markers E-cadherin as well as up-regulated N-cadherin and vimentin in SGC7901 cells, with typical morphological changes of EMT. Tipα also promoted proliferation and migration of SGC7901 cells. Furthermore, Tipα activated interleukin-6 (IL-6)/STAT3 signaling pathway in SGC7901 cells. The effects of Tipα treatment observed was abolished when we block IL-6/STAT3 signaling pathway. Altogether, our data demonstrated that Tipα may accelerate tumor aggressiveness in gastric cancer by promoting EMT through activation of IL-6/STAT3 pathway.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Cell Movement physiology
Cell Proliferation physiology
Humans
Stomach Neoplasms metabolism
Bacterial Proteins physiology
Epithelial-Mesenchymal Transition physiology
Interleukin-6 metabolism
STAT3 Transcription Factor metabolism
Signal Transduction
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 484
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 28130110
- Full Text :
- https://doi.org/10.1016/j.bbrc.2017.01.110