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Islet Cell Yield Following Remote Total Pancreatectomy With Islet Autotransplant is Independent of Cold Ischemia Time.
- Source :
-
Pancreas [Pancreas] 2017 Mar; Vol. 46 (3), pp. 380-384. - Publication Year :
- 2017
-
Abstract
- Objectives: Total pancreatectomy with islet autotransplantation is increasingly being performed remotely, that is, removing the pancreas in 1 location, isolating the islet cells in another location, then returning the islets to the original location for reimplantation into the patient. We determined the influence of extended cold ischemia time on key clinical outcomes in remote islet autotransplantation.<br />Methods: We evaluated patients who underwent remote islet autotransplantation at 2 centers from 2011 to 2014. Patients were divided into 2 groups: those with and those without a decrease in C-peptide greater than 50% from baseline. The primary clinical outcome was the quantity of isolated islet equivalents per kilogram body weight (IEQs/kg).<br />Results: Twenty-five patients met inclusion criteria; 15 had a decrease in C-peptide greater than 50% from baseline and had lower corresponding IEQs/kg compared with those without a decrease greater than 50% (4045 vs 6654 IEQs/kg, P = 0.01). There was no difference in cold ischemia time between the 2 groups (664 vs 600 minutes, P = 0.25). Daily insulin use at 1 year nearly met statistical significance (25.3 vs 8 U, P = 0.06), as did glycated hemoglobin (8.07 vs 6.69 mmol/L, P = 0.06).<br />Conclusions: Cold ischemia time does not influence islet yield in patients undergoing pancreatectomy with remote isolation.
- Subjects :
- Acute Disease
Adult
C-Peptide blood
Female
Humans
Linear Models
Male
Middle Aged
Pancreatitis surgery
Pancreatitis, Chronic surgery
Retrospective Studies
Time Factors
Transplantation, Autologous
Treatment Outcome
Cold Ischemia methods
Islets of Langerhans surgery
Islets of Langerhans Transplantation methods
Pancreatectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 28129232
- Full Text :
- https://doi.org/10.1097/MPA.0000000000000792