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Current and future developments in the treatment of virus-induced hypercytokinemia.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2017 Feb; Vol. 9 (2), pp. 169-178. Date of Electronic Publication: 2017 Jan 27. - Publication Year :
- 2017
-
Abstract
- Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.
- Subjects :
- Animals
Antiviral Agents chemistry
Birds immunology
Birds virology
Cytokines blood
Cytokines immunology
Dengue blood
Dengue complications
Dengue pathology
Hemorrhagic Fever, Ebola blood
Hemorrhagic Fever, Ebola complications
Hemorrhagic Fever, Ebola pathology
Humans
Inflammation complications
Inflammation immunology
Inflammation pathology
Influenza in Birds blood
Influenza in Birds complications
Influenza in Birds pathology
Antiviral Agents pharmacology
Antiviral Agents therapeutic use
Cytokines antagonists & inhibitors
Dengue immunology
Hemorrhagic Fever, Ebola immunology
Inflammation prevention & control
Influenza in Birds immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28128003
- Full Text :
- https://doi.org/10.4155/fmc-2016-0181