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Involvement of FvSet1 in Fumonisin B1 Biosynthesis, Vegetative Growth, Fungal Virulence, and Environmental Stress Responses in Fusarium verticillioides.
- Source :
-
Toxins [Toxins (Basel)] 2017 Jan 24; Vol. 9 (2). Date of Electronic Publication: 2017 Jan 24. - Publication Year :
- 2017
-
Abstract
- Fusarium verticillioides (teleomorph, Gibberella moniliformis ) is an important plant pathogen that causes seedling blight, stalk rot, and ear rot in maize ( Zea mays ). During infection, F. verticillioides produce fumonsins B1 (FB1) that pose a serious threat to human and animal health. Recent studies showed that Set1, a methyltransferase of H3K4, was responsible for toxin biosynthesis in filamentous fungi. However, to date, the regulation of FvSet1 on FB1 biosynthesis remains unclear. In the current study, we identified only one Set1 ortholog in F. verticillioides (FvSet1) and found that the deletion of FvSET1 led to various defects in fungal growth and pathogenicity. More interestingly, the FvSET1 deletion mutant (ΔFvSet1) showed a significant defect in FB1 biosynthesis and lower expression levels of FUM genes. FvSet1 was also found to play an important role in the responses of F. verticillioides to multiple environmental stresses via regulating the phosphorylation of FvMgv1 and FvHog1. Taken together, these results indicate that FvSet1 plays essential roles in the regulation of FB1 biosynthesis, fungal growth and virulence, as well as various stress responses in F. verticillioides.
- Subjects :
- Computational Biology
Databases, Genetic
Fusarium genetics
Fusarium growth & development
Fusarium pathogenicity
Gene Deletion
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Enzymologic
Genotype
Histone-Lysine N-Methyltransferase genetics
Phenotype
Sequence Deletion
Virulence
Food Microbiology
Fumonisins metabolism
Fusarium enzymology
Histone-Lysine N-Methyltransferase metabolism
Stress, Physiological
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 28125013
- Full Text :
- https://doi.org/10.3390/toxins9020043