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YAP/TAZ initiate and maintain Schwann cell myelination.
YAP/TAZ initiate and maintain Schwann cell myelination.
- Source :
-
ELife [Elife] 2017 Jan 26; Vol. 6. Date of Electronic Publication: 2017 Jan 26. - Publication Year :
- 2017
-
Abstract
- Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.<br />Competing Interests: The authors declare that no competing interests exist.
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 28124973
- Full Text :
- https://doi.org/10.7554/eLife.20982