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YAP/TAZ initiate and maintain Schwann cell myelination.

YAP/TAZ initiate and maintain Schwann cell myelination.

Authors :
Grove M
Kim H
Santerre M
Krupka AJ
Han SB
Zhai J
Cho JY
Park R
Harris M
Kim S
Sawaya BE
Kang SH
Barbe MF
Cho SH
Lemay MA
Son YJ
Source :
ELife [Elife] 2017 Jan 26; Vol. 6. Date of Electronic Publication: 2017 Jan 26.
Publication Year :
2017

Abstract

Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.<br />Competing Interests: The authors declare that no competing interests exist.

Details

Language :
English
ISSN :
2050-084X
Volume :
6
Database :
MEDLINE
Journal :
ELife
Publication Type :
Academic Journal
Accession number :
28124973
Full Text :
https://doi.org/10.7554/eLife.20982