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Chemotherapy for dogs with lymph node metastasis from histiocytic sarcomas.
- Source :
-
Australian veterinary journal [Aust Vet J] 2017 Jan; Vol. 95 (1-2), pp. 37-40. - Publication Year :
- 2017
-
Abstract
- Background: Histiocytic sarcomas (HS) frequently metastasise, most commonly to visceral sites, but also to regional lymph nodes. Nodal metastases are associated with a poorer prognosis. This retrospective study aimed to evaluate prognostic factors, including the effect of adjuvant chemotherapy, on survival in dogs with nodal, but not systemic, metastases from HS.<br />Methods: Retrospective case series of 12 dogs with histologically diagnosed HS metastatic to lymph nodes treated with surgery with and without adjuvant chemotherapy.<br />Results: All dogs had histological evidence of metastasis to lymph nodes, with no clinical evidence for metastasis to viscera. Eight dogs that received chemotherapy had a median estimated survival of 219 days (range 77-1638 days); 1- and 2-year estimated survival rates were 37.7%. Median survival time for 4 dogs with nodal metastases that did not receive chemotherapy was 57 days (range 39-136 days) with none alive 1 year after surgery CONCLUSION: Survival for dogs with only regional nodal metastases from HS appeared to be improved by adjuvant chemotherapy.<br /> (© 2017 Australian Veterinary Association.)
- Subjects :
- Animals
Dog Diseases pathology
Dog Diseases surgery
Dogs
Female
Histiocytic Sarcoma drug therapy
Histiocytic Sarcoma pathology
Histiocytic Sarcoma surgery
Lymph Nodes pathology
Lymphatic Metastasis
Male
Prognosis
Retrospective Studies
Survival
Survival Analysis
Chemotherapy, Adjuvant veterinary
Dog Diseases drug therapy
Histiocytic Sarcoma veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1751-0813
- Volume :
- 95
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Australian veterinary journal
- Publication Type :
- Academic Journal
- Accession number :
- 28124419
- Full Text :
- https://doi.org/10.1111/avj.12522