Back to Search
Start Over
Rab27a/Slp2-a complex is involved in Schwann cell myelination.
- Source :
-
Neural regeneration research [Neural Regen Res] 2016 Nov; Vol. 11 (11), pp. 1830-1838. - Publication Year :
- 2016
-
Abstract
- Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized. Our previous results demonstrated that a small GTPase Rab27a regulates lysosomal exocytosis and myelin protein trafficking in Schwann cells. In this present study, we established a dorsal root ganglion (DRG) neuron and Schwann cell co-culture model to identify the signals associated with Rab27a during myelination. First, Slp2-a, as the Rab27a effector, was endogenously expressed in Schwann cells. Second, Rab27a expression significantly increased during Schwann cell myelination. Finally, Rab27a and Slp2-a silencing in Schwann cells not only reduced myelin protein expression, but also impaired formation of myelin-like membranes in DRG neuron and Schwann cell co-cultures. Our findings suggest that the Rab27a/Slp2-a complex affects Schwann cell myelination in vitro .<br />Competing Interests: Conflicts of Interest: None declared.
Details
- Language :
- English
- ISSN :
- 1673-5374
- Volume :
- 11
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Neural regeneration research
- Publication Type :
- Academic Journal
- Accession number :
- 28123429
- Full Text :
- https://doi.org/10.4103/1673-5374.194755