Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats.

Authors :: Zhao Y
Liu Y
Lan XM
Xu GL
Sun YZ
Li F
Liu HN
Source :: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2016; Vol. 2016, pp. 1213090. Date of Electronic Publication: 2016 Dec 29.
Publication Year :: 2016
Abstract: Dendrobium officinale (Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of Dendrobium officinale . However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect of Dendrobium officinale on cancer, and its pharmacological mechanism was explored. Dendrobium officinale extracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose of Dendrobium officinale extracts significantly inhibited the rate of carcinogenesis. Further analysis revealed that Dendrobium officinale extracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer.<br />Competing Interests: The authors declare that they have no conflict of interests.