Back to Search
Start Over
Treatment-associated toxicities reported by patients with early-stage invasive breast cancer.
- Source :
-
Cancer [Cancer] 2017 Jun 01; Vol. 123 (11), pp. 1925-1934. Date of Electronic Publication: 2017 Jan 24. - Publication Year :
- 2017
-
Abstract
- Background: Patient-reported toxicities help to appraise the breast cancer treatment experience. Yet extant data come from clinical trials and health care claims, which may be biased. Using patient surveys, the authors sought to quantify the frequency, severity, and burden of treatment-associated toxicities.<br />Methods: Between 2013 and 2014, the iCanCare study surveyed a population-based sample of women residing in Los Angeles County and Georgia with early-stage, invasive breast cancer. The authors assessed the frequency and severity of toxicities; correlated toxicity severity with unscheduled health care use (clinic visits, emergency department visits/hospitalizations) and physical health; and examined patient, tumor, and treatment factors associated with reporting increased toxicity severity.<br />Results: The overall survey response rate was 71%. From the analyzed cohort of 1945 women, 866 (45%) reported at least 1 toxicity that was severe/very severe, 9% reported unscheduled clinic visits for toxicity management, and 5% visited an emergency department or hospital. Factors associated with reporting higher toxicity severity included receipt of chemotherapy (odds ratio [OR], 2.2; 95% confidence interval [95% CI], 2.0-2.5), receipt of both chemotherapy and radiotherapy (OR, 1.3; 95% CI, 1.0-1.7), and Latina ethnicity (OR vs whites: 1.3; 95% CI, 1.1-1.5). A nonsignificant increase in at least 1 severe/very severe toxicity report was observed for bilateral mastectomy recipients (OR, 1.2; 95% CI, 1.0-1.4).<br />Conclusions: Women with early-stage invasive breast cancer report substantial treatment-associated toxicities and related burden. Clinicians should collect toxicity data routinely and offer early intervention. Toxicity differences observed by treatment modality may inform decision making. Cancer 2017;123:1925-1934. © 2017 American Cancer Society.<br /> (© 2017 American Cancer Society.)
- Subjects :
- Breast Neoplasms pathology
Cancer Pain etiology
Carcinoma pathology
Chemoradiotherapy, Adjuvant
Chemotherapy, Adjuvant
Constipation etiology
Diarrhea etiology
Dyspnea etiology
Edema etiology
Emergency Service, Hospital statistics & numerical data
Female
Hospitalization statistics & numerical data
Humans
Lymph Nodes pathology
Mastectomy, Segmental adverse effects
Middle Aged
Nausea etiology
Neoplasm Invasiveness
Neoplasm Staging
Odds Ratio
Postoperative Complications etiology
Radiodermatitis etiology
Radiotherapy, Adjuvant
Severity of Illness Index
Vomiting etiology
Antineoplastic Agents adverse effects
Breast Neoplasms therapy
Carcinoma therapy
Mastectomy adverse effects
Radiotherapy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 123
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 28117882
- Full Text :
- https://doi.org/10.1002/cncr.30547