The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.

Authors :: Sansone C
Galasso C
Orefice I
Nuzzo G
Luongo E
Cutignano A
Romano G
Brunet C
Fontana A
Esposito F
Ianora A
Source :: Scientific reports [Sci Rep] 2017 Jan 24; Vol. 7, pp. 41215. Date of Electronic Publication: 2017 Jan 24.
Publication Year :: 2017
Abstract: Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E <subscript>2</subscript> (PGE <subscript>2</subscript> ) levels in cells damaged by H <subscript>2</subscript> O <subscript>2</subscript> and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm <superscript>TM</superscript> ) indicating a potential cosmeceutical activity of this microalgal species.

Subjects :: Antioxidants chemistry
Antioxidants isolation & purification
Carotenoids isolation & purification
Carotenoids pharmacology
Cell Line, Tumor
Epidermis drug effects
Epidermis metabolism
Humans
Hydrogen Peroxide pharmacology
Pigments, Biological chemistry
Pigments, Biological isolation & purification
Antioxidants pharmacology
Chlorophyta chemistry
Microalgae chemistry
Oxidative Stress
Pigments, Biological pharmacology

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