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Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity.
- Source :
-
Molecular nutrition & food research [Mol Nutr Food Res] 2017 Aug; Vol. 61 (8). Date of Electronic Publication: 2017 Mar 02. - Publication Year :
- 2017
-
Abstract
- Scope: We evaluated the long-term effect of low-dose nobiletin (NOB), a polymethoxylated flavone, on diet-induced obesity and related metabolic disturbances.<br />Methods and Results: C57BL/6J mice were fed a high-fat diet (HFD, 45 kcal% fat) with or without NOB (0.02%, w/w) for 16 weeks. NOB did not alter food intake or body weight. Despite increases in fatty acid oxidation-related genes expression and enzymes activity in adipose tissue, NOB did not affect adipose tissue weight due to simultaneous increases in lipogenic genes expression and fatty acid synthase activity. However, NOB significantly decreased not only pro-inflammatory genes expression in adipose tissue but also proinflammatory cytokine levels in plasma. NOB-supplemented mice also showed improved glucose tolerance and insulin resistance, along with decreased levels of plasma insulin, free fatty acids, total cholesterol, non-HDL-cholesterol, and apolipoprotein B. In addition, NOB caused significant decreases in hepatic lipid droplet accumulation and triglyceride content by activating hepatic fatty acid oxidation-related enzymes. Hepatic proinflammatory TNF-α mRNA expression, collagen accumulation, and plasma levels of aminotransferases, liver damage indicators, were also significantly lower in NOB-supplemented mice.<br />Conclusion: These findings suggest that long-term supplementation with low-dose NOB can protect against HFD-induced inflammation, insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease, without ameliorating adiposity.<br /> (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Adipose Tissue drug effects
Animals
Body Weight drug effects
Cytokines blood
Diet, High-Fat adverse effects
Dietary Supplements
Dyslipidemias diet therapy
Dyslipidemias etiology
Flavones pharmacology
Hepatitis etiology
Lipids blood
Liver drug effects
Liver metabolism
Male
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease etiology
Obesity etiology
Flavones administration & dosage
Hepatitis diet therapy
Insulin Resistance
Non-alcoholic Fatty Liver Disease diet therapy
Obesity complications
Subjects
Details
- Language :
- English
- ISSN :
- 1613-4133
- Volume :
- 61
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecular nutrition & food research
- Publication Type :
- Academic Journal
- Accession number :
- 28116779
- Full Text :
- https://doi.org/10.1002/mnfr.201600889