Back to Search
Start Over
Nasal neuron PET imaging quantifies neuron generation and degeneration.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2017 Feb 01; Vol. 127 (2), pp. 681-694. Date of Electronic Publication: 2017 Jan 23. - Publication Year :
- 2017
-
Abstract
- Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. [11C]GV1-57 additionally measured rates of neuron regeneration after acute injury and early-stage OSN deficits in a rodent tauopathy model of neurodegenerative disease. Preliminary assessment in nonhuman primates suggested maintained uptake and saturable binding of [18F]GV1-57 in primate nasal epithelium, supporting its translational potential. Future applications for GV1-57 include monitoring additional diseases or conditions associated with olfactory dysregulation, including cognitive decline, as well as monitoring effects of neuroregenerative or neuroprotective therapeutics.<br />Competing Interests: G.C. Van de Bittner and J.M. Hooker are inventors on a patent application related to this work (Radiolabeled compounds for imaging – PCT/US2015/040971). M.J. O’Neill, Z. Ahmed, and T.K. Murray receive a salary for their work at Eli Lilly and Co. Ltd.
- Subjects :
- Animals
Male
Olfaction Disorders physiopathology
Olfactory Nerve physiopathology
Olfactory Pathways physiopathology
Radioactive Tracers
Rats
Rats, Sprague-Dawley
Tauopathies physiopathology
Aging
Olfaction Disorders diagnostic imaging
Olfactory Nerve diagnostic imaging
Olfactory Pathways diagnostic imaging
Positron-Emission Tomography methods
Tauopathies diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1558-8238
- Volume :
- 127
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 28112682
- Full Text :
- https://doi.org/10.1172/JCI89162