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Serotonin 5-HT 4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus.
- Source :
-
Neuroscience letters [Neurosci Lett] 2017 Feb 15; Vol. 640, pp. 111-116. Date of Electronic Publication: 2017 Jan 17. - Publication Year :
- 2017
-
Abstract
- The dorsal raphe nucleus (DRN) is a major serotonin (5-hydroxytryptamine, 5-HT)-producing region in the central nervous system. It receives glutamatergic inputs from several brain regions, which are reciprocally modulated by serotonergic signals. We investigated whether serotonin 5-HT <subscript>4</subscript> receptors (5-HT <subscript>4</subscript> Rs) play a role in the development of glutamatergic control of the DRN, with an emphasis on cortical inputs. Double-label immunohistochemistry and confocal microscopy were used to quantify vesicular glutamate transporter 1 (vGluT1)-immunoreactive terminals in the DRN of mice with a null-mutation in the 5-HT <subscript>4</subscript> R gene. We found no significant change in the overall density of vGluT1-positive terminals in homozygous and heterozygous mice, but heterozygous mice had a significantly higher density of vGluT1-positive terminals contacting serotonergic neurons. These results suggest that altered 5-HT <subscript>4</subscript> R expression may affect the development of cortical glutamatergic control of the DRN.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Heterozygote
Homozygote
Mice
Mice, Knockout
Mutation
Presynaptic Terminals metabolism
Receptors, Serotonin, 5-HT4 genetics
Serotonergic Neurons metabolism
Vesicular Glutamate Transport Protein 1 metabolism
Glutamic Acid metabolism
Raphe Nuclei physiology
Receptors, Serotonin, 5-HT4 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 640
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 28108396
- Full Text :
- https://doi.org/10.1016/j.neulet.2017.01.029