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Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report.
- Source :
-
Transplantation proceedings [Transplant Proc] 2017 Jan - Feb; Vol. 49 (1), pp. 181-184. - Publication Year :
- 2017
-
Abstract
- Although everolimus, a mammalian target of rapamycin inhibitor, has been used as a potent immunosuppressive agent in organ transplantation, data regarding its adverse effect profile compared with that of sirolimus in clinical circumstances are limited. A 50-year-old man who underwent simultaneous liver and kidney transplantation 14 months previously was admitted with large pleural effusion, pericardial effusion, and ascites. Laboratory findings and cultures for possible infectious causes were all negative. Pericardial window surgery with drainage of the pericardial fluid was performed on day 3. Pleural and pericardial biopsy revealed non-specific inflammation without evidence of malignant cells. Everolimus was discontinued and replaced by mycophenolate mofetil on day 4. Significant clinical improvement was observed after discontinuation of everolimus, and follow-up echocardiography and chest radiography showed no recurrence of the pericardial or pleural effusion after discharge.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Ascites chemically induced
Diabetic Nephropathies complications
Drainage
Echocardiography
Humans
Immunosuppressive Agents therapeutic use
Kidney Failure, Chronic etiology
Kidney Failure, Chronic surgery
Liver Cirrhosis, Alcoholic surgery
Male
Middle Aged
Pericardial Effusion diagnostic imaging
Pericarditis chemically induced
Pericarditis diagnostic imaging
Pericarditis pathology
Pleural Effusion diagnostic imaging
Pleurisy chemically induced
Pleurisy diagnostic imaging
Pleurisy pathology
Prednisolone therapeutic use
Serositis diagnostic imaging
Serositis pathology
Tacrolimus therapeutic use
Tomography, X-Ray Computed
Everolimus adverse effects
Graft Rejection prevention & control
Immunosuppressive Agents adverse effects
Kidney Transplantation
Liver Transplantation
Pericardial Effusion chemically induced
Pleural Effusion chemically induced
Serositis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 28104132
- Full Text :
- https://doi.org/10.1016/j.transproceed.2016.11.026