Back to Search
Start Over
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2017 Jan 14; Vol. 22 (1). Date of Electronic Publication: 2017 Jan 14. - Publication Year :
- 2017
-
Abstract
- A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the  pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases.
- Subjects :
- Animals
Antibodies, Monoclonal therapeutic use
Antibodies, Monoclonal, Humanized
Autoimmune Diseases genetics
Autoimmune Diseases immunology
Autoimmune Diseases pathology
Forkhead Transcription Factors antagonists & inhibitors
Forkhead Transcription Factors genetics
Gene Expression Regulation
Humans
Inflammation
Interleukin-17 antagonists & inhibitors
Interleukin-17 genetics
Interleukin-17 immunology
Nuclear Receptor Subfamily 1, Group F, Member 3 antagonists & inhibitors
Nuclear Receptor Subfamily 1, Group F, Member 3 genetics
Piperidines therapeutic use
Pyrimidines therapeutic use
Pyrroles therapeutic use
Signal Transduction
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory pathology
Th17 Cells immunology
Th17 Cells pathology
Ustekinumab therapeutic use
Autoimmune Diseases drug therapy
Forkhead Transcription Factors immunology
Immunologic Factors therapeutic use
Nuclear Receptor Subfamily 1, Group F, Member 3 immunology
T-Lymphocytes, Regulatory drug effects
Th17 Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 28098832
- Full Text :
- https://doi.org/10.3390/molecules22010134