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Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice.
- Source :
-
The British journal of nutrition [Br J Nutr] 2017 Jan; Vol. 117 (1), pp. 21-29. Date of Electronic Publication: 2017 Jan 17. - Publication Year :
- 2017
-
Abstract
- Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of N ε -(carboxymethyl)-l-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr389, an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis.
- Subjects :
- Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Diet
Gene Expression Regulation drug effects
Glycation End Products, Advanced toxicity
Lysine analogs & derivatives
Lysine metabolism
Male
Mice
Mice, Inbred ICR
Myogenic Regulatory Factors genetics
Myogenic Regulatory Factors metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Glycation End Products, Advanced administration & dosage
Muscle Contraction drug effects
Muscle, Skeletal growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 117
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 28093090
- Full Text :
- https://doi.org/10.1017/S0007114516004591