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Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Jan; Vol. 162 (3), pp. 316-319. Date of Electronic Publication: 2017 Jan 16. - Publication Year :
- 2017
-
Abstract
- Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.
- Subjects :
- Animals
Animals, Outbred Strains
Electromyography
Electron Spin Resonance Spectroscopy
Female
Male
Muscle, Skeletal drug effects
Neuromuscular Junction drug effects
Nitric Oxide antagonists & inhibitors
Nitric Oxide Synthase Type I antagonists & inhibitors
Psychomotor Performance drug effects
Rats
Spinal Cord drug effects
Spinal Cord pathology
Spinal Cord Injuries pathology
Spinal Cord Injuries physiopathology
Enzyme Inhibitors pharmacology
NG-Nitroarginine Methyl Ester pharmacology
Nitric Oxide biosynthesis
Nitric Oxide Synthase Type I metabolism
Spinal Cord enzymology
Spinal Cord Injuries enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 162
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28091928
- Full Text :
- https://doi.org/10.1007/s10517-017-3604-6