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ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
- Source :
-
Scientific reports [Sci Rep] 2017 Jan 16; Vol. 7, pp. 40273. Date of Electronic Publication: 2017 Jan 16. - Publication Year :
- 2017
-
Abstract
- ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that recognize glycolipid antigens in the context of CD1d-mediated antigen presentation. In this study, we demonstrate that ABCA7 regulates the development of NKT cells in a cell-extrinsic manner. We found that in Abca7 <superscript>-/-</superscript> mice there is reduced expression of CD1d accompanied by an alteration in lipid raft content on the plasma membrane of thymocytes and antigen presenting cells. Together, these alterations caused by absence of ABCA7 negatively affect NKT cell development and function.
- Subjects :
- ATP-Binding Cassette Transporters genetics
ATP-Binding Cassette Transporters immunology
Animals
Female
Male
Membrane Microdomains immunology
Mice, Inbred C57BL
Mice, Knockout
Natural Killer T-Cells immunology
ATP-Binding Cassette Transporters metabolism
Antigens, CD1d metabolism
Membrane Microdomains metabolism
Natural Killer T-Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28091533
- Full Text :
- https://doi.org/10.1038/srep40273