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Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.
- Source :
-
Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2017 Jan; Vol. 3 (1), pp. 119-128. - Publication Year :
- 2017
-
Abstract
- Background and Aims: There is a pressing need to develop effective preventative therapies for post-ERCP pancreatitis (PEP). We demonstrated that early PEP events are induced through the calcium-activated phosphatase calcineurin and that global calcineurin deletion abolishes PEP in mice. A crucial question is whether acinar cell calcineurin controls the initiation of PEP in vivo .<br />Methods: We used a mouse model of PEP and examined the effects of in vivo acinar cell-specific calcineurin deletion by either generating a conditional knockout line or infusing a novel AAV-Ela-iCre into the pancreatic duct of a calcineurin floxed line.<br />Results: We found that PEP is dependent on acinar cell calcineurin in vivo , and this led us to determine that calcineurin inhibitors, infused within the radiocontrast, can largely prevent PEP.<br />Conclusions: These results provide impetus for launching clinical trials to test the efficacy of intraductal calcineurin inhibitors to prevent PEP.
Details
- Language :
- English
- ISSN :
- 2352-345X
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cellular and molecular gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 28090570
- Full Text :
- https://doi.org/10.1016/j.jcmgh.2016.08.006