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Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.
- Source :
-
Experimental and molecular pathology [Exp Mol Pathol] 2017 Feb; Vol. 102 (1), pp. 115-122. Date of Electronic Publication: 2017 Jan 11. - Publication Year :
- 2017
-
Abstract
- Gliomas, especially low-grade gliomas, are highly epileptogenic brain tumors. Histopathological information is valuable in evaluating the diagnosis and/or biologic behavior of various gliomas. Here we explored the clinical data and histopathological predictors of the occurrence of epilepsy in patients with gliomas. A retrospective study examined 310 consecutive patients who had undergone surgical treatment for gliomas in our institution from January 2013 to January 2015. Clinical data and pathological examination results were analyzed. Literatures regarding the predictors and etiology of glioma associated epileptic seizures in the period of 1995-2015 were also reviewed. A total of 234 (75.5%) astrocytic tumors and 76 (24.5%) oligodendrial tumors were included. At diagnosis, 33.6% of patients had epileptic seizures. Multivariate analysis revealed cortex involvement (OR=7.991, 95%CI=1.599-39.926), lower World Health Organization grade (OR=3.584, 95%CI=1.032-12.346) and topoisomerase II (TopoII) positivity (OR=0.943, 95%CI=0.903-0.982) were strong predictors for preoperative epileptic seizures. Gender, disease course, tumor classification, location or volume did not significantly affect epileptic seizure occurrence. Forty-three publications involved glioma-associated epilepsy were found in PubMed online database and key data were extracted and summarized. The present studies on glioma-related epilepsy are relatively limited and inconsistent. Low-grade gliomas, cortex involvement and TopoII positivity were independent predictors of a history of epileptic seizures at diagnosis. Further studies to examine the underlying mechanism of topoisomerase II as well as other molecules in epilepsy occurrence in brain gliomas are needed in the future.<br /> (Copyright © 2017. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Aged
Brain metabolism
Brain pathology
Brain Neoplasms enzymology
Brain Neoplasms surgery
Child
China epidemiology
Comorbidity
Epilepsy enzymology
Female
Glioma enzymology
Glioma surgery
Humans
Immunohistochemistry
Male
Middle Aged
Multivariate Analysis
Neoplasm Grading
Preoperative Period
Prognosis
Retrospective Studies
Young Adult
Brain Neoplasms epidemiology
DNA Topoisomerases, Type II metabolism
Epilepsy epidemiology
Glioma epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0945
- Volume :
- 102
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental and molecular pathology
- Publication Type :
- Academic Journal
- Accession number :
- 28087392
- Full Text :
- https://doi.org/10.1016/j.yexmp.2017.01.005