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Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs).
- Source :
-
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2017 Aug; Vol. 1858 (8), pp. 615-627. Date of Electronic Publication: 2017 Jan 10. - Publication Year :
- 2017
-
Abstract
- Until 1972, the term 'apoptosis' was used to differentiate the programmed cell death that naturally occurs in organismal development from the acute tissue death referred to as necrosis. Many studies on cell death and programmed cell death have been published and most are, at least to some degree, related to cancer. Some key proteins and molecular pathways implicated in cell death have been analyzed, whereas others are still being actively researched; therefore, an increasing number of cellular compartments and organelles are being implicated in cell death and cancer. Here, we discuss the mitochondria and subdomains of the endoplasmic reticulum (ER) that interact with mitochondria, the mitochondria-associated membranes (MAMs), which have been identified as critical hubs in the regulation of cell death and tumor growth. MAMs-dependent calcium (Ca <superscript>2+</superscript> ) release from the ER allows selective Ca <superscript>2+</superscript> uptake by the mitochondria. The perturbation of Ca <superscript>2+</superscript> homeostasis in cancer cells is correlated with sustained cell proliferation and the inhibition of cell death through the modulation of Ca <superscript>2+</superscript> signaling. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Calcium Channels physiology
Calcium Signaling physiology
Cell Death
Cell Division
Cell Transformation, Neoplastic
Disease Progression
Endoplasmic Reticulum metabolism
Homeostasis
Humans
Membrane Proteins physiology
Mitochondrial Membranes ultrastructure
Mitochondrial Proteins physiology
Neoplasm Proteins physiology
Oncogene Proteins physiology
Signal Transduction
Calcium physiology
Mitochondria physiology
Mitochondrial Membranes physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0005-2728
- Volume :
- 1858
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Bioenergetics
- Publication Type :
- Academic Journal
- Accession number :
- 28087257
- Full Text :
- https://doi.org/10.1016/j.bbabio.2017.01.003