Room Temperature Regioselective Catalytic Hydrodefluorination of Fluoroarenes with trans-[Ru(NHC) 4 H 2 ] through a Concerted Nucleophilic Ru-H Attack Pathway.

Authors :: Cybulski MK
McKay D
Macgregor SA
Mahon MF
Whittlesey MK
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Feb 01; Vol. 56 (6), pp. 1515-1519. Date of Electronic Publication: 2017 Jan 09.
Publication Year :: 2017
Abstract: The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe <subscript>4</subscript> ) <subscript>4</subscript> H <subscript>2</subscript> ] catalyst, 3, is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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