Back to Search
Start Over
Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?
- Source :
-
Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2017 Feb; Vol. 34, pp. 1-6. Date of Electronic Publication: 2016 Sep 20. - Publication Year :
- 2017
-
Abstract
- Objective: The decline in insulin sensitivity (S <subscript>I</subscript> ) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing S <subscript>I</subscript> in adolescents with T1D.<br />Methods: Thirteen adolescents with T1D (HbA1C 8.2 ± 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning.<br />Results: Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50% versus 33%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 ± 1 mg • kg <superscript>-1</superscript> • min <superscript>-1</superscript> versus 7.0 ± 1; glutamine versus placebo; P = 0.4).<br />Conclusions: Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Blood Glucose metabolism
Body Mass Index
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Fatty Acids, Nonesterified blood
Female
Glucagon-Like Peptide 1 blood
Glucose Clamp Technique
Humans
Hypoglycemia drug therapy
Hypoglycemic Agents administration & dosage
Insulin blood
Male
Diabetes Mellitus, Type 1 drug therapy
Exercise
Glutamine administration & dosage
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1244
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- Nutrition (Burbank, Los Angeles County, Calif.)
- Publication Type :
- Academic Journal
- Accession number :
- 28063503
- Full Text :
- https://doi.org/10.1016/j.nut.2016.09.003