Back to Search
Start Over
New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation.
- Source :
-
Cell stem cell [Cell Stem Cell] 2017 Jan 05; Vol. 20 (1), pp. 18-28. - Publication Year :
- 2017
-
Abstract
- Pathways underlying mouse embryonic development have always informed efforts to derive, maintain, and drive differentiation of human pluripotent stem cells. However, direct application of mouse embryology to the human system has not always been successful because of fundamental developmental differences between species. The naive pluripotent state of mouse embryonic stem cells (ESCs), in particular, has been difficult to capture in human ESCs, and appears to be transitory in the human embryo itself. Further studies of human and non-human primate embryo development are needed to untangle the complexities of pluripotency networks across mammalian species.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1875-9777
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell stem cell
- Publication Type :
- Academic Journal
- Accession number :
- 28061351
- Full Text :
- https://doi.org/10.1016/j.stem.2016.12.004