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Enantioselective Synthesis of Chiral Oxygen-Containing Heterocycles Using Copper-Catalyzed Aryl C-O Coupling Reactions via Asymmetric Desymmetrization.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2017 Feb 03; Vol. 82 (3), pp. 1458-1463. Date of Electronic Publication: 2017 Jan 20. - Publication Year :
- 2017
-
Abstract
- An enantioselective desymmetric aryl C-O coupling reaction was demonstrated under the catalysis of CuI and a chiral cyclic diamine ligand. A series of chiral oxygen-containing heterocyclic units such as 2,3-dihydrobenzofurans, chromans, and 1,4-benzodioxanes with tertiary or quaternary stereocarbon centers were synthesized with this method. DFT calculations were also carried out for a better understanding of the model for enantiocontrol.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28054776
- Full Text :
- https://doi.org/10.1021/acs.joc.6b02646