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Pharmacokinetics of superoxide dismutase during hypothermic cardiopulmonary bypass.
- Source :
-
Circulation [Circulation] 1989 Nov; Vol. 80 (5 Pt 2), pp. III25-9. - Publication Year :
- 1989
-
Abstract
- We evaluated the plasma elimination of recombinant human superoxide dismutase (rHSOD) when given before reperfusion in an experimental canine model of global hypothermic myocardial ischemia. Adult mongrel dogs were placed on cardiopulmonary bypass, and core temperature was reduced to 25 degrees C. Hypothermic global myocardial ischemia was maintained for 90 minutes with intermittent crystalloid cardioplegic solution. Five minutes before reperfusion, rHSOD was administered via the pump oxygenator as a bolus injection. Plasma rHSOD levels were measured at 0, 3, 5, 10, 20, 30, 60, and 120 minutes after injection. Animals were rewarmed and weaned from bypass. Three experimental groups received either 4, 8, or 16 mg/kg rHSOD. Based on previously reported dose-response data, we conclude that desirable peak serum concentrations are achieved with 16 mg/kg rHSOD. In the setting of hypothermic cardiopulmonary bypass and global myocardial ischemia, single bolus administration of rHSOD before reperfusion is an effective method due to the prolonged serum half-life.
- Subjects :
- Animals
Dogs
Female
Free Radicals
Heart Arrest, Induced
Hypothermia, Induced
Male
Myocardial Reperfusion Injury etiology
Recombinant Proteins pharmacokinetics
Superoxide Dismutase administration & dosage
Time Factors
Cardiopulmonary Bypass
Myocardial Reperfusion Injury prevention & control
Superoxide Dismutase pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0009-7322
- Volume :
- 80
- Issue :
- 5 Pt 2
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 2805304