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Genetic Variants in MTHFR Gene Predict ≥ 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy.
- Source :
-
PloS one [PLoS One] 2017 Jan 03; Vol. 12 (1), pp. e0169147. Date of Electronic Publication: 2017 Jan 03 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Reactive oxygen species (ROS), formed as an indirect production of radiotherapy (RT), could cause DNA damage of normal tissues. Meanwhile, our body possesses the ability to restore the damage by DNA repair pathways. The imbalance between the two systems could finally result in radiation injury. Therefore, in this prospective cohort study, we explored the association of genetic variants in ROS metabolism and DNA repair pathway-related genes with radiation pneumonitis (RP). A total of 265 locally advanced esophageal squamous cell carcinoma (ESCC) patients receiving RT in Chinese Han population were enrolled. Five functional single nucleotide polymorphisms (SNPs) (rs1695 in GSTP1; rs4880 in SOD2; rs3957356 in GSTA1; and rs1801131, rs1801133 in MTHFR) were genotyped using the MassArray system, and rs1801131 was found to be a predictor of ≥ 2 RP. Our results showed that, compared with TT genotype, patients with GG/GT genotypes of rs1801131 had a notably lower risk of developing ≥ 2 RP (HR = 0.339, 95% CI = 0.137-0.839, P = 0.019). Further independent studies are required to confirm this findings.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell genetics
China
DNA Repair
Esophageal Neoplasms genetics
Female
Genotype
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Prospective Studies
Radiation Pneumonitis etiology
Reactive Oxygen Species metabolism
Young Adult
Carcinoma, Squamous Cell radiotherapy
Esophageal Neoplasms radiotherapy
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Polymorphism, Single Nucleotide
Radiation Pneumonitis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28046029
- Full Text :
- https://doi.org/10.1371/journal.pone.0169147