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Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2017 Apr; Vol. 76 (4), pp. 670-675. Date of Electronic Publication: 2016 Dec 29. - Publication Year :
- 2017
-
Abstract
- Background: Biologics seem to offer a promising nonsurgical approach in hidradenitis suppurativa (HS), especially in disease with highly pronounced inflammation. Recent studies revealed increased expression of a broad range of cytokines in lesional HS skin, including interleukin (IL)-17.<br />Objective: This study was undertaken to determine IL-17 serum levels in this group of patients.<br />Methods: Our study was conducted on a group of 86 patients between 16 and 72 years of age with HS. A total of 86 matched healthy volunteers constituted the control group. Enzyme-linked immunosorbent assay kits were used to quantify IL-17 serum concentration.<br />Results: The mean IL-17 serum level of patients with HS was 3.68 ± 2.08 pg/mL, which was significantly elevated (P < .0001) compared with that found in healthy volunteers (2.5 ± 1.11 pg/mL). Moreover, there was a tendency toward higher serum concentrations of IL-17 in patients with more advanced disease (P = .005). Disease duration; patient sex, age, and body mass index; and smoking habits were not determining factors for IL-17 serum concentration.<br />Limitations: Hospital-based study population was a limitation, as was a lack of posttreatment assessment.<br />Conclusion: In light of our findings and literature on increased expression of IL-17 in HS lesions, evaluating the clinical effectiveness of using anti-IL-17 agents in the treatment of patients with HS is justified.<br /> (Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Biomarkers
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Female
Hidradenitis Suppurativa drug therapy
Humans
Interleukin-17 antagonists & inhibitors
Male
Middle Aged
Severity of Illness Index
Smoking epidemiology
Young Adult
Dermatologic Agents therapeutic use
Hidradenitis Suppurativa blood
Immunosuppressive Agents therapeutic use
Interleukin-17 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6787
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 28041632
- Full Text :
- https://doi.org/10.1016/j.jaad.2016.10.042