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Rapid transmission of multidrug-resistant Corynebacterium striatum among susceptible patients in a tertiary hospital in China.
- Source :
-
Journal of infection in developing countries [J Infect Dev Ctries] 2016 Dec 30; Vol. 10 (12), pp. 1299-1305. Date of Electronic Publication: 2016 Dec 30. - Publication Year :
- 2016
-
Abstract
- Introduction: With increasing reports about Corynebacterium striatum, its potential pathogenicity and clinical significance are drawing more attention in recent years.<br />Methodology: During a 14-month period, Corynebacterium striatum strains were routinely isolated in lower respiratory tract samples of the inpatients in a tertiary hospital in China, and the suspected isolates were identified with VITEK-2 ANC card and 16S rRNA sequencing technique, respectively. Pulsed-field gel electrophoresis (PFGE) was employed to discriminate different clones, and biofilm-producing abilities of different strains were compared.<br />Results: A total of 82 strains of Corynebacterium striatum were mainly isolated from neurosurgery patients (45.1%, 37/82). Three epidemic clones (type D, F, and I) were identified, accounting for 82.9% (68/82) of strains. All 82 C. striatum strains were all sensitive to vancomycin, and resistant to ceftriaxone, imipenem, and ciprofloxacin. One week before C. striatum isolation, 89.0% (73/82) patients showed lower levels of hemoglobin, 93.9% (77/82) of patients received treatment of several kinds of antibiotics, and 41.5% (34/82) patients with glucocorticoid, and 46.3% (38/82) of patients showed disturbed consciousness at different levels.<br />Conclusions: Corynebacterium striatum strains isolated during this study were mainly multidrug resistant, and the predominant clones could rapidly transmit among susceptible inpatients. Corynebacterium striatum seems to be an important pathogen for patients with specific risk factors, especially for the ones with lower hemoglobin levels who are being treated with broad-spectrum antibiotics.
- Subjects :
- Adolescent
Adult
Anti-Bacterial Agents pharmacology
Bacterial Typing Techniques
Biofilms growth & development
Child
Child, Preschool
China epidemiology
Corynebacterium classification
Corynebacterium genetics
Corynebacterium physiology
Corynebacterium Infections microbiology
Corynebacterium Infections transmission
Cross Infection microbiology
Cross Infection transmission
DNA, Bacterial chemistry
DNA, Bacterial genetics
DNA, Ribosomal chemistry
DNA, Ribosomal genetics
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Female
Genotype
Humans
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Molecular Typing
RNA, Ribosomal, 16S genetics
Respiratory Tract Infections microbiology
Respiratory Tract Infections transmission
Sequence Analysis, DNA
Tertiary Care Centers
Young Adult
Corynebacterium isolation & purification
Corynebacterium Infections epidemiology
Cross Infection epidemiology
Disease Transmission, Infectious
Respiratory Tract Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1972-2680
- Volume :
- 10
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of infection in developing countries
- Publication Type :
- Academic Journal
- Accession number :
- 28036309
- Full Text :
- https://doi.org/10.3855/jidc.7577