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Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Apr 01; Vol. 72 (4), pp. 998-1001. - Publication Year :
- 2017
-
Abstract
- Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia.<br />Methods: The whole genomes of 18 randomly selected vanA -positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed.<br />Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn 1546 variants and plasmid backbone structures.<br />Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single 'dominant' ST or vanA -encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.<br /> (© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Australia epidemiology
DNA Transposable Elements
Enterococcus faecium drug effects
Enterococcus faecium genetics
Genome, Bacterial
Gram-Positive Bacterial Infections epidemiology
Hospitals
Humans
Molecular Typing
Plasmids analysis
Sequence Analysis, DNA
Bacterial Proteins genetics
Carbon-Oxygen Ligases genetics
Enterococcus faecium classification
Enterococcus faecium isolation & purification
Genetic Variation
Gram-Positive Bacterial Infections microbiology
Vancomycin-Resistant Enterococci classification
Vancomycin-Resistant Enterococci genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2091
- Volume :
- 72
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28031272
- Full Text :
- https://doi.org/10.1093/jac/dkw539