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Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells.
- Source :
-
Neurogastroenterology and motility [Neurogastroenterol Motil] 2017 Jan; Vol. 29 (1). - Publication Year :
- 2017
-
Abstract
- As current options for treating most enteric neuropathies are either non-effective or associated with significant ongoing problems, cell therapy is a potential attractive possibility to treat congenital and acquired neuropathies. Studies using animal models have shown that following transplantation of enteric neural progenitors into the bowel of recipients, the transplanted cells migrate, proliferate, and generate neurons that are electrically active and receive synaptic inputs. Recent studies have transplanted human enteric neural progenitors into the mouse colon and shown engraftment. In this article, we summarize the significance of these recent advances and discuss priorities for future research that might lead to the use of regenerative medicine to treat enteric neuropathies in the clinic.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Enteric Nervous System physiology
Hirschsprung Disease diagnosis
Hirschsprung Disease physiopathology
Hirschsprung Disease therapy
Humans
Intestinal Pseudo-Obstruction diagnosis
Intestinal Pseudo-Obstruction physiopathology
Regenerative Medicine methods
Stem Cell Transplantation methods
Treatment Outcome
Intestinal Pseudo-Obstruction therapy
Neural Stem Cells transplantation
Regenerative Medicine trends
Stem Cell Transplantation trends
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2982
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurogastroenterology and motility
- Publication Type :
- Academic Journal
- Accession number :
- 28028898
- Full Text :
- https://doi.org/10.1111/nmo.12993