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Fowl typhoid in laying hens cause hepatic oxidative stress.
- Source :
-
Microbial pathogenesis [Microb Pathog] 2017 Feb; Vol. 103, pp. 162-166. Date of Electronic Publication: 2016 Dec 24. - Publication Year :
- 2017
-
Abstract
- The aim of this study was to analyses nitric oxide, antioxidant status, and oxidative profile in the liver of laying hens naturally infected by Salmonella enterica subsp enterica serovar Gallinarum (S. Gallinarum). The nitrite/nitrate (NO <subscript>x</subscript> ), reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities were measured in liver samples, as well the biomarkers of hepatic function (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), total protein and albumin levels measured in serum. NO <subscript>x</subscript> levels and CAT activity were reduced in hepatic tissue of infected hens. On the other hand, TBARS and ROS levels, GR, GPx and GST activities were higher in infected animals. On biomarkers of tissue damage, ALT, AST, GGT and total protein levels were higher in serum of infected hens, and showed decreased albumin levels. In summary, ROS and TBARS production lead to damage on the membrane lipids that alter activities of antioxidant enzymes CAT, GR, GPx and GSH, an adaptive response against S. Gallinarum infection, contributing to the pathophysiology and clinical signs of the disease.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Catalase metabolism
Glutathione metabolism
Glutathione Transferase metabolism
Liver metabolism
Nitric Oxide
Oxidation-Reduction
Poultry Diseases microbiology
Poultry Diseases pathology
Reactive Oxygen Species
Salmonella Infections, Animal microbiology
Salmonella Infections, Animal pathology
Chickens
Liver microbiology
Liver pathology
Oxidative Stress
Poultry Diseases metabolism
Salmonella Infections, Animal metabolism
Salmonella enterica
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1208
- Volume :
- 103
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 28027943
- Full Text :
- https://doi.org/10.1016/j.micpath.2016.12.009