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A comprehensive assessment of cognitive function in the common genetic generalized epilepsy syndromes.
- Source :
-
European journal of neurology [Eur J Neurol] 2017 Mar; Vol. 24 (3), pp. 453-460. Date of Electronic Publication: 2016 Dec 27. - Publication Year :
- 2017
-
Abstract
- Background and Purpose: Considered to be benign conditions, the common genetic generalized epilepsy (GGE) syndromes are now known to be frequently accompanied by cognitive dysfunction. However, unresolved issues impede clinical management of this common comorbidity, including which cognitive abilities are most affected, whether there are differences between syndromes and how seizure type and mood symptoms affect cognitive dysfunction. We provide a detailed description of cognitive ability and evaluate factors contributing to cognitive dysfunction.<br />Methods: A total of 76 adults with GGE were assessed with the Woodcock Johnson III Tests of Cognitive Abilities.<br />Results: Scores on tests of overall cognitive ability, acquired knowledge, long-term retrieval and speed of information processing were significantly below the normative mean. Long-term retrieval was a pronounced weakness with a large reduction in scores (d = 0.84). GGE syndrome, seizure type and the presence of recent psychopathology symptoms were not significantly associated with cognitive function.<br />Conclusions: This study confirms previous meta-analytic findings with a prospective study, offers new insights into the cognitive comorbidity of these common epilepsy syndromes and reinforces the need for cognitive interventions in people with GGE.<br /> (© 2016 EAN.)
- Subjects :
- Adolescent
Adult
Epilepsy, Generalized complications
Epileptic Syndromes
Female
Humans
Male
Mental Disorders diagnosis
Mental Disorders etiology
Mental Disorders psychology
Mental Processes
Mental Recall
Middle Aged
Prospective Studies
Reference Values
Reproducibility of Results
Seizures physiopathology
Seizures psychology
Young Adult
Cognition
Epilepsy, Generalized genetics
Epilepsy, Generalized psychology
Neuropsychological Tests
Subjects
Details
- Language :
- English
- ISSN :
- 1468-1331
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28026919
- Full Text :
- https://doi.org/10.1111/ene.13232