Back to Search
Start Over
Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media.
- Source :
-
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2017 Mar; Vol. 23 (3), pp. 136-141. Date of Electronic Publication: 2016 Dec 23. - Publication Year :
- 2017
-
Abstract
- Background: This prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of Streptococcus pneumoniae identified in Korean children with acute otitis media (AOM) after the introduction of a 7-valent pneumococcal conjugate vaccine (PCV7).<br />Methods: Nasopharyngeal aspirates were collected from children diagnosed with AOM in seven hospitals in Korea. The bacteria identified in these samples and the serotypes, sequence types (STs), and antibiotic susceptibilities of S. pneumoniae isolates were evaluated.<br />Results: A total of 390 children were enrolled, and bacteria were identified in 376 (96.4%) children. S. pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were identified in 155 (39.7%), 127 (32.6%) and 86 (22.1%) children, respectively. Serotype 19A (22.4%) was the most common S. pneumoniae serotype, with serogroups 11 (14.7%) and 15 (13.5%) following. ST320 (23.5%) was the most common ST; ST166 (17.0%) and ST83 (8.5%) followed. The overall susceptibility rates of S. pneumoniae to oral penicillin V and amoxicillin/clavulanate were 2.6% and 53.2%, respectively. The susceptibility rate to cefditoren was 91.0%; however, the rates for other cephalosporins were less than 10.0%. Compared with other serogroups, S. pneumoniae serogroups 19, 11, and 15 showed significantly lower susceptibility rates to all the antibiotics tested.<br />Conclusion: S. pneumoniae serotype 19A, serogroups 11 and 15 were the major nasopharyngeal-colonizing bacteria in Korean children with AOM after the introduction of PCV7. These relatively prevalent serotype/serogroups showed lower antibiotic susceptibility rates.<br /> (Copyright © 2016. Published by Elsevier Ltd.)
- Subjects :
- Anti-Bacterial Agents immunology
Child
Child, Preschool
Haemophilus influenzae isolation & purification
Humans
Infant
Infant, Newborn
Microbial Sensitivity Tests methods
Moraxella catarrhalis isolation & purification
Nasopharynx immunology
Otitis Media immunology
Pneumococcal Infections immunology
Pneumococcal Vaccines immunology
Prevalence
Prospective Studies
Republic of Korea epidemiology
Serogroup
Serotyping methods
Streptococcus pneumoniae immunology
Vaccines, Conjugate immunology
Acute Disease epidemiology
Nasopharynx microbiology
Otitis Media microbiology
Pneumococcal Infections epidemiology
Pneumococcal Infections microbiology
Streptococcus pneumoniae isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7780
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28024738
- Full Text :
- https://doi.org/10.1016/j.jiac.2016.10.006