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Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.
- Source :
-
Frontiers in immunology [Front Immunol] 2016 Dec 05; Vol. 7, pp. 564. Date of Electronic Publication: 2016 Dec 05 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that, in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interaction with B cells in the acute phase of lymphocytic choriomeningitis virus (LCMV) infection. This impairment was limited to the T cell-dependent B cell response and was associated with disruption of B cell follicles, development of hypergammaglobulinemia (HGG), and expansion of the T follicular helper cell population. Antigen-specific antibody responses were restored by ablation of IFN-I signaling through antibody-mediated IFN-I receptor blockade and B cell-specific IFN-I receptor knockout. Importantly, IFN-I receptor deficiency in B cells also accelerated the development of LCMV neutralizing antibodies and alleviated HGG. These results provide a potential therapeutic target toward efficient treatment measures that limit immunopathology in persistent viral infections.
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27994594
- Full Text :
- https://doi.org/10.3389/fimmu.2016.00564