Various Sequence Types of Escherichia coli Isolates Coharboring bla NDM-5 and mcr-1 Genes from a Commercial Swine Farm in China.

Authors :: Kong LH
Lei CW
Ma SZ
Jiang W
Liu BH
Wang YX
Guan R
Men S
Yuan QW
Cheng GY
Zhou WC
Wang HN
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Feb 23; Vol. 61 (3). Date of Electronic Publication: 2017 Feb 23 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Sixteen different sequence types (STs) of Escherichia coli isolates from a commercial swine farm in China were confirmed to coharbor the carbapenem resistance gene bla <subscript>NDM-5</subscript> and the colistin resistance gene mcr-1 Whole-genome sequencing revealed that bla <subscript>NDM-5</subscript> and mcr-1 were located on a 46-kb IncX3 plasmid and a 32-kb IncX4 plasmid, respectively. The two plasmids can transfer together with a low fitness cost, which might explain the presence of various STs of E. coli coharboring bla <subscript>NDM-5</subscript> and mcr-1 .<br /> (Copyright © 2017 American Society for Microbiology.)

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