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Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol.
- Source :
-
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2017 Jan 28; Vol. 246, pp. 79-87. Date of Electronic Publication: 2016 Dec 18. - Publication Year :
- 2017
-
Abstract
- The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping α-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. In addition, the intravenous administration of tocotrienol entrapped in transferrin-bearing vesicles resulted in tumor suppression for 30% of A431 and 60% of B16-F10 tumors, without visible toxicity. Mouse survival was enhanced by >13days compared to controls administered with the drug solution only. This tumor-targeted, tocotrienol-based nanomedicine therefore significantly improved the therapeutic response in cancer treatment.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Intravenous
Animals
Antioxidants therapeutic use
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Cell Line, Tumor
Drug Carriers metabolism
Female
Humans
Melanoma, Experimental metabolism
Melanoma, Experimental pathology
Mice
Mice, Inbred BALB C
Tocotrienols therapeutic use
Transferrin metabolism
Antioxidants administration & dosage
Carcinoma, Squamous Cell drug therapy
Drug Delivery Systems
Melanoma, Experimental drug therapy
Tocotrienols administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4995
- Volume :
- 246
- Database :
- MEDLINE
- Journal :
- Journal of controlled release : official journal of the Controlled Release Society
- Publication Type :
- Academic Journal
- Accession number :
- 27993600
- Full Text :
- https://doi.org/10.1016/j.jconrel.2016.12.014