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Phenylpropanoids from Juglans mandshurica exhibit cytotoxicities on liver cancer cell lines through apoptosis induction.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Feb 01; Vol. 27 (3), pp. 597-601. Date of Electronic Publication: 2016 Dec 05. - Publication Year :
- 2017
-
Abstract
- Three new phenylpropanoids (1-3) together with six known congeners (4-9) were isolated from the bark of Juglans mandshurica Maxim using anti-hepatoma activity as a guide. Their structures were determined by comprehensive NMR and HRESIMS spectroscopic data analyses. All the isolated compounds were evaluated for their growth inhibitory activities against two kinds of liver cancer cell lines (HepG2 and Hep3B). Among them, compound 4 showed moderate cytotoxic activities against HepG2 and Hep3B cell lines with IC <subscript>50</subscript> values of 58.58 and 69.87μM. Compound 5 exhibited 50% cell death rate in HepG2 and Hep3B cell lines at 63.70 and 46.45μM, respectively. Further observation of morphological changes and Western blot demonstrated that compounds 4 and 5 exhibited their cytotoxic activities through the induction of apoptosis. A structure-activity relationship study suggested that an α, β-unsaturated aldehyde might be the most important functional group.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Cell Line, Tumor
Hep G2 Cells
Humans
Juglans metabolism
Liver Neoplasms metabolism
Liver Neoplasms pathology
Magnetic Resonance Spectroscopy
Molecular Conformation
Plant Bark chemistry
Plant Bark metabolism
Plant Extracts chemistry
Plant Extracts pharmacology
Propanols isolation & purification
Structure-Activity Relationship
Apoptosis drug effects
Juglans chemistry
Propanols chemistry
Propanols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 27993516
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.12.005