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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.
- Source :
-
Kidney international [Kidney Int] 2017 Mar; Vol. 91 (3), pp. 539-551. Date of Electronic Publication: 2016 Dec 16. - Publication Year :
- 2017
-
Abstract
- In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.<br /> (Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Atypical Hemolytic Uremic Syndrome drug therapy
Atypical Hemolytic Uremic Syndrome genetics
Atypical Hemolytic Uremic Syndrome pathology
Complement C3 genetics
Complement Inactivating Agents therapeutic use
Genetic Predisposition to Disease
Glomerulonephritis drug therapy
Glomerulonephritis genetics
Glomerulonephritis pathology
Humans
Kidney drug effects
Kidney pathology
Phenotype
Risk Factors
Treatment Outcome
Atypical Hemolytic Uremic Syndrome immunology
Complement Activation drug effects
Complement C3 immunology
Glomerulonephritis immunology
Kidney immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 91
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Kidney international
- Accession number :
- 27989322
- Full Text :
- https://doi.org/10.1016/j.kint.2016.10.005