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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

Authors :
Goodship TH
Cook HT
Fakhouri F
Fervenza FC
Frémeaux-Bacchi V
Kavanagh D
Nester CM
Noris M
Pickering MC
Rodríguez de Córdoba S
Roumenina LT
Sethi S
Smith RJ
Source :
Kidney international [Kidney Int] 2017 Mar; Vol. 91 (3), pp. 539-551. Date of Electronic Publication: 2016 Dec 16.
Publication Year :
2017

Abstract

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.<br /> (Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1523-1755
Volume :
91
Issue :
3
Database :
MEDLINE
Journal :
Kidney international
Accession number :
27989322
Full Text :
https://doi.org/10.1016/j.kint.2016.10.005