Back to Search
Start Over
Ischemic Postconditioning Before Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction Reduces Contrast-induced Nephropathy and Improves Long-term Prognosis.
- Source :
-
Archives of medical research [Arch Med Res] 2016 Aug; Vol. 47 (6), pp. 483-488. - Publication Year :
- 2016
-
Abstract
- Background and Aims: Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is one of the major adverse outcomes affecting the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). Ischemic postconditioning prior to PCI (pre-PCI) in patients with STEMI is hypothesized to be protective against CIN after PCI.<br />Methods: A total of 251 patients with STEMI were randomized into two groups: ischemic postconditioning group (n = 123, age, 61.1 ± 12.5 years) who underwent ischemic postconditioning prior to PCI; control group (n = 128; age, 64.1 ± 12.1 years) who underwent only PCI. Ischemic postconditioning was administered by three cycles of deflation and inflation of the balloon (1-min ischemia and 1-min reperfusion) starting 1 min after infarct-related artery (IRA) opening. Diagnostic criterion for CIN was: increase in serum creatinine level by ≥0.5 mg/dL or by ≥25% increase from preoperative level within 48 h of surgery. All patients were followed for 1 year for incidence of major cardiovascular events (MACE).<br />Results: The incidence of postoperative CIN in the ischemic postconditioning group was 5.69% as compared to 14.06% in the control group (p <0.05). At one year, the MACE incidence in the ischemic postconditioning group was 7.32% as compared to 15.63% in the control group (p <0.05).<br />Conclusions: Pre-PCI ischemic postconditioning in STEMI patients significantly reduces the post-PCI incidence of CIN and improves long-term prognosis.<br /> (Copyright © 2016 IMSS. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Female
Humans
Kidney Diseases chemically induced
Male
Middle Aged
Myocardial Infarction diagnosis
Myocardial Infarction diagnostic imaging
Prognosis
Treatment Outcome
Contrast Media adverse effects
Ischemic Postconditioning
Kidney Diseases prevention & control
Myocardial Infarction therapy
Percutaneous Coronary Intervention
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5487
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 27986129
- Full Text :
- https://doi.org/10.1016/j.arcmed.2016.10.001