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Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2017; Vol. 56 (2), pp. 453-458. - Publication Year :
- 2017
-
Abstract
- Cardiovascular Risk factors, Aging and Dementia (CAIDE) is a Finnish population-based study. 731 cognitively normal women had self-reported hormone therapy (HT) data in 1998 as: no use, use ≤5 years, and >5 years. Information on type of HT was only available from 1995-1998 (Prescription Register). Cognition was assessed in 1998 and 2005-2008. Long-term (>5 years) HT use, especially use of estradiol alone among women having hysterectomy with bilateral oophorectomy, was associated with better episodic memory in 1998, but not in 2005-2008. Although a strong evidence for protective effect of estradiol on cognition was not observed in our study, improved global cognition among long-term users suggests that long-term postmenopausal HT may be beneficial for some cognitive domains.
- Subjects :
- Aged
Aging psychology
Female
Finland
Follow-Up Studies
Humans
Hysterectomy
Longitudinal Studies
Memory, Episodic
Neuropsychological Tests
Ovariectomy
Postmenopause
Prospective Studies
Risk Factors
Self Report
Aging drug effects
Cardiovascular Diseases epidemiology
Cognition drug effects
Dementia epidemiology
Estradiol therapeutic use
Hormone Replacement Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 56
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 27983549
- Full Text :
- https://doi.org/10.3233/JAD-160643