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Armanni-Ebstein Lesions in Terminal Hyperglycemia.
- Source :
-
Journal of forensic sciences [J Forensic Sci] 2017 Jul; Vol. 62 (4), pp. 921-925. Date of Electronic Publication: 2016 Dec 16. - Publication Year :
- 2017
-
Abstract
- Armanni-Ebstein lesions (AEL) occur in deaths related to uncontrolled diabetes mellitus. To investigate the relationship between AEL and terminal hyperglycemia, we retrospectively reviewed 71 cases with vitreous glucose levels ≥11.1 mmol/L; 27 (38%) cases had AEL (vitreous glucose 14.0-77.3 mmol/L); and 44 cases (62%) did not (vitreous glucose 11.1-91.9 mmol/L). There was no significant difference (p = 0.271) in vitreous glucose levels between the cases with AEL (mean 39.2, SD 16.7 mmol/L) and those without (mean 34.2, SD 19.8 mmol/L). Similarly, there was no difference in the degree of dehydration, renal failure, or osmolality. However, there was a significantly higher level of β-hydroxybutyrate among the cases with AEL compared to those without (p = 0.007), suggesting that ketoacidosis may facilitate the development of AEL. Given the possible synergistic role of β-hydroxybutyrate, the correlation between AEL and terminal hyperglycemia in animal studies may not be applicable to humans. AEL may also possibly occur with sublethal elevations in glucose.<br /> (© 2016 American Academy of Forensic Sciences.)
- Subjects :
- 3-Hydroxybutyric Acid metabolism
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Glucose metabolism
Humans
Ketosis pathology
Male
Middle Aged
Retrospective Studies
Vitreous Body metabolism
Young Adult
Epithelial Cells pathology
Hyperglycemia pathology
Kidney Tubules cytology
Vacuoles pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-4029
- Volume :
- 62
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of forensic sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27982446
- Full Text :
- https://doi.org/10.1111/1556-4029.13360