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The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.
- Source :
-
Metabolic brain disease [Metab Brain Dis] 2017 Apr; Vol. 32 (2), pp. 513-518. Date of Electronic Publication: 2016 Dec 15. - Publication Year :
- 2017
-
Abstract
- Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality. Liver disease leads to hyperammonemia and ammonia toxicity is believed to play a major role in the pathogenesis of hepatic encephalopathy. However, the effects of ammonia are not brain-specific and therefore may also affect other organs and tissues including muscle. The precise pathophysiological mechanisms underlying muscle wasting in chronic liver disease remains to be elucidated. In the present study, we characterized body composition as well as muscle protein synthesis in cirrhotic rats with hepatic encephalopathy using the 6-week bile duct ligation (BDL) model which recapitulates the main features of cirrhosis. Compared to sham-operated control animals, BDL rats display significant decreased gain in body weight, altered body composition, decreased gastrocnemius muscle mass and circumference as well as altered muscle morphology. Muscle protein synthesis was also significantly reduced in BDL rats compared to control animals. These findings demonstrate that the 6-week BDL experimental rat is a relevant model to study liver disease-induced muscle mass loss.
- Subjects :
- Ammonia blood
Animals
Base Composition
Disease Models, Animal
Eating
Hepatic Encephalopathy
Hyperammonemia etiology
Hyperammonemia pathology
Ligation
Male
Muscle Proteins metabolism
Rats
Rats, Sprague-Dawley
Weight Gain
Bile Ducts
Liver Cirrhosis, Experimental pathology
Muscle, Skeletal pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7365
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Metabolic brain disease
- Publication Type :
- Academic Journal
- Accession number :
- 27981407
- Full Text :
- https://doi.org/10.1007/s11011-016-9937-4