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Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations.
- Source :
-
Oncotarget [Oncotarget] 2017 Jan 17; Vol. 8 (3), pp. 4387-4398. - Publication Year :
- 2017
-
Abstract
- The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia.
- Subjects :
- Adult
Africa
Age Factors
Asia
Child
Europe
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Genotype
Humans
Leukemia classification
Male
United States
Air Pollution adverse effects
Leukemia genetics
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Mutation
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 27966457
- Full Text :
- https://doi.org/10.18632/oncotarget.13876