Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission.

Authors :: Mischnik A
Baumert P
Hamprecht A
Rohde A
Peter S
Feihl S
Knobloch J
Gölz H
Kola A
Obermann B
Querbach C
Willmann M
Gebhardt F
Tacconelli E
Gastmeier P
Seifert H
Kern WV
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2017 Feb; Vol. 49 (2), pp. 239-242. Date of Electronic Publication: 2016 Nov 28.
Publication Year :: 2017
Abstract: As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC <subscript>50/90</subscript> values were 0.25-4 mg/L for cefepime/tazobactam, 0.25-2 mg/L for ceftazidime/avibactam, 0.125-0.5 mg/L for ceftaroline/avibactam, 0.5-4 mg/L for cefpodoxime/clavulanic acid and 0.25-1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, β-lactam antibiotics play an important role in the treatment of infections due to β-lactamase-producing organisms.<br /> (Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.)

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