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PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery.
- Source :
-
The Indian journal of medical research [Indian J Med Res] 2016 Aug; Vol. 144 (2), pp. 181-193. - Publication Year :
- 2016
-
Abstract
- Current treatment methods for melanoma have some limitations such as less target-specific action, severe side effects and resistance to drugs. Significant progress has been made in exploring novel drug delivery systems based on suitable biochemical mechanisms using nanoparticles ranging from 10 to 400 nm for drug delivery and imaging, utilizing their enhanced penetration and retention properties. Poly-lactide-co-glycolide (PLGA), a copolymer of poly-lactic acid and poly-glycolic acid, provides an ideally suited performance-based design for better penetration into skin cells, thereby having a greater potential for the treatment of melanoma. Moreover, encapsulation protects the drug from deactivation by biological reactions and interactions with biomolecules, ensuring successful delivery and bioavailability for effective treatment. Controlled and sustained delivery of drugs across the skin barrier that otherwise prohibits entry of larger molecules can be successfully made with adequately stable biocompatible nanocarriers such as PLGA for taking drugs through the small cutaneous pores permitting targeted deposition and prolonged drug action. PLGA is now being extensively used in photodynamic therapy and targeted therapy through modulation of signal proteins and drug-DNA interactions. Recent advances made on these nanomedicines and their advantages in the treatment of skin melanoma are highlighted and discussed in this review.<br />Competing Interests: None.
- Subjects :
- Humans
Lactic Acid chemistry
Melanoma pathology
Nanomedicine
Nanoparticles chemistry
Polyglycolic Acid chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Drug Delivery Systems
Lactic Acid therapeutic use
Melanoma drug therapy
Nanoparticles therapeutic use
Polyglycolic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0971-5916
- Volume :
- 144
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Indian journal of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 27934796
- Full Text :
- https://doi.org/10.4103/0971-5916.195024