Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.

Authors :: Torriani G
Galan-Navarro C
Kunz S
Source :: Journal of virology [J Virol] 2017 Jan 31; Vol. 91 (4). Date of Electronic Publication: 2017 Jan 31 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.<br /> (Copyright © 2017 American Society for Microbiology.)