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What is the best therapy for Whipple's disease? Our point of view.
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2017 Apr; Vol. 52 (4), pp. 465-466. Date of Electronic Publication: 2016 Dec 07. - Publication Year :
- 2017
-
Abstract
- Although Whipple's disease (WD) has been treated with antibiotics since the early 50s, the best antibiotics and the duration of the therapy have not yet been established. We consider here the pro and cons of the two most commonly used therapies, ceftriaxone followed by trimethoprim-sulfamethoxazole (TMP-SMZ) and hydroxychloroquine in combination with doxycycline. The therapy based on ceftriaxone and TMP-SMZ is efficient in the vast majority of patients for the first few years. However, since reinfections or reactivations can occur, a life-long prophylaxis is necessary and doxycycline is nowadays the best option. We thus propose a therapy based on merging these to therapies together, ceftriaxone, and TMP-SMZ for the first year(s) and then life-long prophylaxis with doxycycline.
- Subjects :
- Drug Therapy, Combination
Feces microbiology
Humans
Randomized Controlled Trials as Topic
Tropheryma drug effects
Anti-Bacterial Agents therapeutic use
Ceftriaxone therapeutic use
Doxycycline therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
Whipple Disease drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7708
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 27924649
- Full Text :
- https://doi.org/10.1080/00365521.2016.1264009