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Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Jan 22; Vol. 482 (4), pp. 1160-1164. Date of Electronic Publication: 2016 Dec 02. - Publication Year :
- 2017
-
Abstract
- The heart produces multiple diffusible factors that are involved in a number of physiological processes, but the action of these factors on the central nervous system is not well understood. In this study, we found that one or more factors released by cardiomyocytes promote oligodendrocyte precursor cell (OPC) proliferation in vitro. Mouse OPCs co-cultured with mouse cardiomyocytes showed higher proliferative ability than OPCs cultured alone. In addition, cardiomyocyte-conditioned media was sufficient to promote OPC proliferation. The phosphorylation of phosphatidylinositol (PI) 3-kinase and extracellular signal-regulated kinase (ERK) in OPCs is necessary for the enhancement of OPC proliferation by cardiomyocyte-conditioned media. These data indicate that heart-derived factors have the ability to directly regulate the function of central nervous system (CNS) cells.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Brain metabolism
Cell Differentiation
Cells, Cultured
Central Nervous System metabolism
Coculture Techniques
Culture Media, Conditioned
Extracellular Signal-Regulated MAP Kinases metabolism
Mice
Mice, Inbred C57BL
Multiple Sclerosis metabolism
Myelin Sheath metabolism
Phosphatidylinositol 3-Kinases metabolism
Phosphorylation
Cell Proliferation
Myocytes, Cardiac cytology
Oligodendroglia cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 482
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27919687
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.12.004